You won't be out of a hotel, if that's your general fear. Granted, the room might not be downtown, but you won't have to sleep outside. Mission Valley hotels usually open up again later in the month and those will be solidly vacant. The shuttle service is very reliable and frequent. It usually runs every 15min during normal hours and every 30min after 12AM. The only downside to the shuttle is that it kills a lot of time to go back-and-forth if you're someone who needs to go back to their hotel frequently (e.g. drop stuff, change, etc). But if you just need a sleeping area then I don't think a room in Mission Valley is that bad.