While hotels will have spots available for guests, I HIGHLY recommend not going that route if you're not going to use your car at all. Parking is expensive ($32/night at the Hilton Bayfront) and trying to navigate around downtown with all the cars/pedestrians/blockages is a nightmare.
Someone else mentioned parking your car at long-term airport parking, and I've done that the last 6 years, and it's been fantastic. $10-15 dollars/day + a cab ride (every driver has been so nice and with some excellent food recommendations to boot), and you don't have to deal with the traffic headache. If you have a bunch of people in the car maybe splitting the parking is cost negligible, but I like to save those dollars for all the coffee I can get.