You can set alerts for certain accounts, but if those accounts tweet a lot of non-SDCC stuff you may get swamped. I keep SDCC's official account on alert and then the week before I set certain shows and groups for events that I want to attend on alert. This cuts down on the non-SDCC stuff.
I find that right before and during comic-con there can be way too much to keep up with. Some accounts will tweet something out every couple of minutes. So instead of monitoring them myself, I wrote bots that do and only inform me if there are certain keywords like "eventbrite", "event", "RSVP" and "register". Worked really well for me last year and I was able to sign up for many events.